Patient Information

    Metal Allergy Testing

    Advanced antibody testing for metal allergies to ensure safe and successful outcomes for dental implants and TMJ joint replacement procedures.

    Why Metal Allergy Testing Matters

    Metal hypersensitivity can affect the success of dental implants and joint replacement surgeries. While rare, some patients develop immune reactions to metals used in prosthetic devices, leading to chronic inflammation, pain, or implant failure.

    Dr. Krajekian performs specialized metal allergy testing in indicated cases to identify potential sensitivities before surgery, ensuring the safest and most appropriate materials are selected for each patient's unique needs.

    Most Accurate Testing Available in the US

    MELISA Test

    Memory Lymphocyte Immunostimulation Assay

    A scientifically validated blood test that measures type IV (delayed) hypersensitivity to metals at the cellular level. It identifies metal-specific memory T-cells that indicate an allergy.

    Highly accurate
    Most specific test for metal hypersensitivity
    Detects delayed-type hypersensitivity (Type IV)
    Can test multiple metals simultaneously
    Results guide material selection for implants
    LTT (Lymphocyte Transformation Test)

    Lymphocyte Transformation Test

    Measures the immune system's cellular response to metal ions by evaluating lymphocyte proliferation when exposed to metal antigens.

    High accuracy
    Validated scientific methodology
    Quantitative measurement of immune response
    Useful for pre-surgical screening
    Identifies sensitization before implant placement

    Common Metal Allergens

    Titanium

    Rare but significant

    While considered biocompatible, some patients develop hypersensitivity reactions to titanium used in dental implants and TMJ prostheses.

    Nickel

    Common

    One of the most common metal allergens. Often found in alloys used in dental and orthopedic devices.

    Cobalt

    Moderate

    Frequently used in combination with chromium in medical-grade alloys for joint replacements.

    Chromium

    Moderate

    Used in stainless steel and cobalt-chromium alloys for prosthetic devices.

    Molybdenum

    Rare

    Found in some titanium alloys and medical-grade metals used in implants.

    Vanadium

    Rare

    Component of Ti-6Al-4V alloy commonly used in orthopedic and dental implants.

    Titanium Allergies & Dental Implants

    Titanium has long been considered the gold standard for dental implants due to its excellent biocompatibility. However, research has shown that a small percentage of patients can develop hypersensitivity reactions to titanium and its alloys.

    Signs of Titanium Sensitivity:

    Unexplained implant failure
    Chronic gum inflammation
    Bone loss around implants
    Persistent discomfort or pain
    Allergic-type skin reactions
    Fatigue or systemic symptoms

    For patients with confirmed titanium sensitivity, alternative implant materials such as zirconia (ceramic) implants may be recommended.

    Metal Allergies & TMJ Joint Replacement

    TMJ (temporomandibular joint) replacement is a complex procedure that requires careful consideration of metal allergies. Unlike dental implants, TMJ prostheses involve multiple metal components and remain in constant motion, making material compatibility even more critical.

    Custom TMJ Prostheses

    TMJ joint replacements are complex devices that remain in the body for decades. Metal allergy testing ensures the selected materials are compatible with your immune system.

    Multiple Metal Components

    TMJ prostheses may contain titanium, cobalt-chromium, and other alloys. Comprehensive testing screens for sensitivity to all potential materials.

    Long-Term Success

    Identifying metal sensitivities before surgery helps prevent complications such as chronic pain, inflammation, or device failure.

    Material Selection

    Test results guide the selection of prosthetic materials, potentially leading to alternative alloys or surface treatments for sensitive patients.

    When Is Testing Recommended?

    Dr. Krajekian may recommend metal allergy testing in the following situations:

    Unexplained implant failures or loosening
    Chronic pain around implant sites
    Local tissue reactions or inflammation
    Systemic symptoms following implant placement
    Family history of metal allergies
    Known skin reactions to jewelry or metal objects
    Previous implant complications

    Dr. Krajekian's Approach

    As a Board Certified Oral and Maxillofacial Surgeon specializing in complex reconstructive procedures, Dr. Krajekian understands the importance of personalized patient care. When indicated, he orders comprehensive metal allergy testing using the most accurate antibody-based methods available in the United States.

    This proactive approach helps ensure optimal outcomes for patients undergoing dental implant placement, TMJ joint replacement, or other procedures involving metal prosthetic components.

    Questions About Metal Allergy Testing?

    If you have concerns about metal allergies or are planning implant surgery, contact our office to discuss whether testing is appropriate for your situation.

    Call (440) 646-0597